Alzheimer's disease

progressive mental deterioration characterized by loss of memory, ability to calculate,and visual-spatial orientation, confusion, disorientation. it begins in late middle life and result in death in 5-10 years.pathologically brain is atrophic, especially in frontal occipetal and temporal region.histologically there is distortion of the intracellular neurofibrils ans senile plaques composed of granular or filamentous argentophilic masses with an amyloid core, found predominently in cerebral cortex, amygdala and hippocampus.cerebral cortex has few and shrunken neurons which may contain cytoplasmic vacuoles and argentophilic granules displacing the neucleus to the periphery