Donepezil (HCl)
Donepezil (HCl) is a piperidine derivative, is a reversible and specific inhibitor of acetylcholinesterase. Donepezil (HCl) is highly selective for the CNS and is used in the symptomatic treatment of mild to moderate dementia in Alzheimer`s disease.
Primary Characteristics
Molecular Weight: 416 · Non-proprietary name: Donepezil (HCl).
Pharmacokinetics
Distribution: Donepezil (HCl) has a volume of distribution is 14.0l/kg. plasma protein binding is 92.6(91.7-93.5)%.
Elimination: it is metabolised via Liver, plasma half-life is 59.7(43.6-75.8)hr, renal excretion is 10.6(7.9-13.3)%.
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Indications
Donepezil (HCl) is primarily indicated in conditions like Alzheimer's disease, Induction of general anaesthesia.
Donepezil (HCl) is also indicated for secondary conditions like Sclerosis, Vascular disease.
Contraindications
Donepezil (HCl) is contraindicated in conditions like Pregnancy, Breast feeding.
Dosage
Donepezil (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5 – 10 mg | — | Every 24h | PO | Mild to Moderate Alzheimer''s Type Dementia: Should be taken in the evening. |
| 20 mg | 20 mg | Every 24h | PO | Moderate to severe Alzheimer''''s Type Dementia: Should be taken in the evening. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Donepezil (HCl) in overdosage may give rise to further complications which include Ataxia , Cataract, Pruritis , Intraperitoneal hemorrhage , Cataract , Supraventricular tachycardia, Skin ulceration, Hirsutism, Conjunctival Hemorrhage, Blepharitis.
Donepezil (HCl) produces potentially life-threatening effects which include Thrombocytopenia , Neuroleptic Malignant Syndrome , Neuroleptic malignant syndrome, Pneumonia . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Donepezil (HCl) are Bradycardia, Hypotension, Convulsions , Sweating , Sweating, Salivation .
Donepezil (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Confusion, Diarrhea, Dizziness, Fatigue, Hallucination , Headache, Insomnia, Muscle cramps, Nausea and vomiting, Pruritus , Psychiatric disturbance, Rashes , Syncope , Urinary incontinence.
Warnings / Precautions
Interference in Pathology
Donepezil (HCl) may interfere in the diagnosis of Not well documented.
Available Brands
Storage Conditions
Drug Classification
- 1.1.4 — Muscle relaxants and cholinesterase inhibitors