Rivastigmine

Drug #997

Rivastigmine is a reversible non-competitive inhibitor of cholinesterases. Rivastigmine is used in alzheimer's dementia to increase brain cholinergic activity.

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Primary Characteristics

It is of Synthetic origin and belongs to Carbamate.

It belongs to Cholinestrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Cholinergic Agonist pharmacological group.

Molecular Weight: 250.3 · Solubility in Water: very soluble · Solubility in Alcohol: soluble · Non-proprietary name: Rivastigmine.

Pharmacokinetics

Distribution: Rivastigmine has a volume of distribution is 1.8-2.7 l/kg. plasma protein binding is 40%.

Elimination: plasma half-life is 1 hr, renal excretion is 90%.

Indications

Rivastigmine is primarily indicated in conditions like Alzheimer's disease, Dementia, Mild to moderate dementia in alzheimer's disease.

Contraindications

Rivastigmine is contraindicated in conditions like Hypersensitivity.

Dosage

Rivastigmine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.5 mg	1.5 mg	Every 12h	PO	Dose may be increased according to the response by 1.5 mg at minimum. 2 week intervals to Max. Dose 6 mg BID.
Paediatric Dosage (20kg)
0 – 0	—	—		Not applicable in paeds
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown10 interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Rivastigmine in overdosage may give rise to further complications which include Urinary tract infection , Respiratory tract infections , Psychiatric disease.

Rivastigmine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Agitation , Anorexia , Asthenia , Confusion, Diarrhea, Dizziness, Fatigue, Headache, Increased intracranial pressure, Insomnia, Malaise, Nausea, SomnolenceX, Sweating , Syncope , Tremor, Vomiting .

Warnings / Precautions

Rivastigmine should be used only if clearly needed during pregnancy. It should be used with caution in patients with asthma, seizure disorder, epilepsy, heart disease such as hypertension, bradycardia, recent myocardial infraction, thyroid disorders, intestinal disorders, ulcers, urinary problems or if have any allergy especially to bromides. Large dose by mouth should be avoided in condition where there may be increased absorption from the gastrointestinal tract. Use of rivastigmine is associated with weight loss and monitoring of patients weight during treatment is recommended.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

1.5 mg 3 mg 4.5 mg 6 mg

Oral Soln

2 mg

Patches

18 mg 4.6 mg 9.5 mg

Tabs SR

3 mg 6 mg

Storage Conditions

Rivastigmine should be stored Caps, Soln.

Drug Classification

1.20 — Muscle relaxants and cholinesterase inhibitors

Manufacturers

Manufacturers of Rivastigmine in Pakistan:

English Genix Novartis Searle