Memantine
Also known as: Amantadine
Memantine (HCl) is a derivative of amantadine. Similar to amantadine, it inhibits enzyme N-methyl-D-aspartate receptors, that affects glutamate transmission. Memantine (HCl) is used in the treatment of mild to moderate dementia in Alzheimer`s disease. Memantine (HCl) is also used in the management of Parkinsonism and cerebral spasticity.
Primary Characteristics
Memantine is also known as Amantadine , Memantine (HCl).
It is of Synthetic origin.
Molecular Weight: 215.8 · Non-proprietary name: Memantine.
Pharmacokinetics
None recorded.
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Indications
Memantine is primarily indicated in conditions like Alzheimer's disease, Induction and maintenance of anaesthesia, Parkinsonism.
Contraindications
Memantine is contraindicated in conditions like Breast feeding.
Dosage
Memantine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5 mg | 5 mg | Every 12h | PO | Initially for 1 week. In morning. |
| 10 mg | 10 mg | Every 24h | PO | Maintenance In divided doses to maximum of 20 mg |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Memantine is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Confusion, Cystitis, Dizziness, Hallucination , Headache, Hypertonia, Tiredness , Vomiting .
Warnings / Precautions
Interference in Pathology
Memantine may interfere in the diagnosis of Urinanalysis .
Available Brands
Drug Classification
- 1.9.1 — Drugs used in parkinsonism