Idebenone
Idebenone is used in the treatment of mental impairment associated with cerebrovascular disorders. It also is used in Alzheimer`s disease.Idebenone is a yellowish orange to orange crystalline solid, powder, or mass, without odor, prepared by chemical symthesis.
Primary Characteristics
It is of Synthetic origin.
Molecular Weight: 338.4 · Solubility in Water: > 1 in 10000 · Solubility in Alcohol: < 1 in 1 · Non-proprietary name: Idebenone.
Pharmacokinetics
Distribution: Idebenone has a volume of distribution is 95.7 litre.
Elimination: it is metabolised via Hepatic, plasma half-life is 1.8-10.6 hr.
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Indications
Idebenone is primarily indicated in conditions like Alzheimer's disease, Cerebral arteriosclerosis, Cerebrovascular disease, Decreased volition, Emotional disturbances, Sequelae of cerebral hemorrhages, Sequelae of cerebral infarction, Speech disturbances.
Idebenone is also indicated for secondary conditions like Cardiomyopathy.
Contraindications
Idebenone is contraindicated in conditions like Hypersensitivity.
Dosage
Idebenone's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5 mg/kg | 5 mg/kg | Every 8h | in 3 divided doses for freid reich''s ataxia. | |
| 90 mg | 90 mg | Every 8h | PO | For Alzheimer''s disease: After food in two divided doses. |
| 105 mg | 105 mg | Every 8h | PO | For Alzheimer's disease: |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Idebenone in overdosage may give rise to further complications which include Leucopenia, Anemia , Poriomania, Hallucinations , Convulsive seizures, Hyperkinesia, Delirium , Tremors .
Idebenone is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Diarrhea, Dizziness, Epigastric pain, Excitement, Headache, Insomnia, Light headedness, Malaise, Nausea.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.24.3 — Drugs used in anxiety and sleep disorders