Naftidrofuryl (Oxalate)

Also known as: Nafroyl, Nofrayl oxalate

Drug #498

Naftidrofuryl (Oxalate) is used as a vasodilator in the treatment of peripheral and cerebral vascular disorders. Naftidrofuryl (Oxalate) is also claimed to enhance cellular oxidative capacity thereby protecting cells against the results of ischaemia.

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Primary Characteristics

Naftidrofuryl (Oxalate) is also known as Nafroyl, Nofrayl oxalate.

It is of Synthetic origin and belongs to Furfuryl Propionate.

It belongs to Vasodilators pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.

Molecular Weight: 473.6 · pK_a: 8.7 · Solubility in Water: readily soluble · Solubility in Alcohol: Freely soluble · Non-proprietary name: Naftidrofuryl (Oxalate).

Molecular structure of Naftidrofuryl (Oxalate)

Pharmacokinetics

Absorption: Naftidrofuryl (Oxalate) has an oral bioavailability is 92.5% (±6.5%), pre-systemic (first-pass) metabolism accounts for 45.5% (±4.5%).

Distribution: Naftidrofuryl (Oxalate) has a volume of distribution is 124.69+-41.12ml/min. plasma protein binding is <80%.

Elimination: it is metabolised via Hepatic, plasma half-life is 1 hr, renal excretion is 80 %.

Indications

Naftidrofuryl (Oxalate) is primarily indicated in conditions like Peripheral vascular disease, Raynaud's phenomenon, Sedative in combined anaesthesia.

Naftidrofuryl (Oxalate) is also indicated for secondary conditions like Alzheimer's disease, Dementia.

Contraindications

None recorded.

Dosage

Naftidrofuryl (Oxalate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
150 mg	150 mg	Every 8h	PO	For at least 3 months
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
0 – 0	—	—		Not indicated in this age group

Drug Interactions

None recorded.

Side Effects

Naftidrofuryl (Oxalate) in overdosage may give rise to further complications which include Hepatitis , Hepatic failure.

The signs and symptoms that are produced after acute overdosage of Naftidrofuryl (Oxalate) are Hypotension, Convulsions , Unconsciousness, Depression of Cardiac conduction.

Naftidrofuryl (Oxalate) is known to cause more or less tolerable side effects which are usually transient. These include Epigastric pain, Nausea, Rashes .

Warnings / Precautions

A sufficient amount of liquid should be taken during treatment to maintain an adequate level of diuresis.

Available Brands

None recorded.

Storage Conditions

Naftidrofuryl (Oxalate) should be stored Caps.

Drug Classification

1.12.3.7 — Direct vasodilators