Rocuronium (Br)
Rocuronium (Br) is a non-depolarizing skeletal muscle rexalant. Rocuronium (Br) is used as an adjunct to anaesthesia. Rocuronium (Br) is a competitive neuromuscular blocking agent. It affects the transmission at the neuromuscualr junction. Rocuronium is an injectable, nondepolarizing neuromuscular blocking drug. It was developed out of a need for an agent with a rapid onset and short duration of action, and a low risk of side effects. Rocuronium's onset of action is comparable to that of succinylcholine, but its duration of action is significantly longer. Compared with other nondepolarizing agents, rocuronium has a similar side effect profile but a more rapid onset of action. Rocuronium was approved by the FDA in March 1994.
Primary Characteristics
It belongs to Amino Steroid.
It is also classified under Muscle Relaxants .
Molecular Weight: 609.7 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Rocuronium (Br).
Pharmacokinetics
Distribution: Rocuronium (Br) has a plasma protein binding is 30 %.
Elimination: it is metabolised via Hepatic, renal excretion is 30 %.
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Indications
Rocuronium (Br) is primarily indicated in conditions like Adjunct to anesthesia, Muscle relaxation (intermediate duration) during intensive care, Muscle relaxation (intermediate duration) for surgery or intubation, Muscular spasm.
Contraindications
None recorded.
Dosage
Rocuronium (Br)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.15 mg/ kg | 0.15 mg/ kg | — | IV | Maintenance as required |
| 0.45 mg/ kg | 0.45 mg/ kg | — | IV | Initially as required |
| 0.45 ug/ kg/min | 0.45 ug/ kg/min | — | IV Inf | Continuous Infusion Dose |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Rocuronium (Br) is known to cause more or less tolerable side effects which are usually transient. These include Bronchospasm, Cardiac arrhythmias , Edema, Hiccups, Hypertension , Nausea, Pruritus , Rashes , Tachycardia, Transient hypotension, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.20 — Muscle relaxants and cholinesterase inhibitors
Manufacturers
Manufacturers of Rocuronium (Br) in Pakistan: