Risperidone - Drug Monograph | DrugInfoSys ODIS

Primary Characteristics

It is of Synthetic origin and belongs to Benzisoxazole.

It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 410.5 · pK_a: 8.2, 3.1 · Solubility in Water: 1 in 15000 · Solubility in Alcohol: 1 in 70 · Non-proprietary name: Risperidone.

Pharmacokinetics

Absorption: Risperidone has an oral bioavailability is 48.5% (±48.5%), pre-systemic (first-pass) metabolism accounts for 27.5% (±7.5%).

Distribution: Risperidone has a volume of distribution is 1.2 l/kg. plasma protein binding is 88%.

Elimination: it is metabolised via Hepatic, plasma half-life is 3 hr, renal excretion is 90%.

Indications

Risperidone is primarily indicated in conditions like Anovulatory infertility, Psychosis, Schizophrenia.

Risperidone is also indicated for secondary conditions like Metastatic melanoma.

Contraindications

Risperidone is contraindicated in conditions like Epilepsy, Phaeochromocytoma, Thyrotoxicosis, Coma, Parkinson's disease, Hypersensitivity.

Dosage

Risperidone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 mg	1 mg	Every 12h	PO	As initial dose. Increase gradually as required.
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown5 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Risperidone in overdosage may give rise to further complications which include Torsades de pointes, Parkinsonism , Ventricular tachycardia , Neuroleptic malignant syndrome .

The signs and symptoms that are produced after acute overdosage of Risperidone are Hypotension, Lethargy, Somnolence, Muscular rigidity.

Risperidone is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Agitation , Anxiety, Blurred vision, Constipation , Dizziness, Fatigue, Headache, Increased intracranial pressure, Insomnia, Nausea, Photosensitivity, Rashes , Rhinitis , Urinary incontinence, Vomiting .

Warnings / Precautions

Risperidone should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with pre-existing kidney disease, liver disease, heart disease, seizure disorder, blood disorders, breast cancer or if have any allergy. It may make patient more sensitive to the sun, avoid prolonged sun exposure, wear protective clothing and use sunscreen when outdoors.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

Oral Soln

Soln

Susp

Tabs

1 mg 2 mg 200 mg 3 mg 4 mg

Storage Conditions

Risperidone should be stored Tab, Soln.

Drug Classification

1.24.1 — Drugs used in psychotic disorders