Sodium Stibogluconate

Also known as: Sodium Antimonygluconate

Drug #667

Sodium Stibogluconate is antiprotozoal, used in the treatment of all types of leishmaniasis along with other drugs (eg; pentamidine and amphotericin B).

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Primary Characteristics

Sodium Stibogluconate is also known as Sodium Antimonygluconate.

It belongs to Antimonic Acid.

It belongs to Antiparasitic pharmacological group on the basis of mechanism of action and also classified in Antiparasitic pharmacological group.

Molecular Weight: 392.8 · pK_a: Acidic · Solubility in Water: freely soluble · Solubility in Alcohol: Poor · Non-proprietary name: Sodium Stibogluconate.

Molecular structure of Sodium Stibogluconate

Pharmacokinetics

Elimination: renal excretion is extensive.

Indications

Sodium Stibogluconate is primarily indicated in conditions like Leishmaniasis, Visceral leishmaniasis.

Contraindications

Sodium Stibogluconate is contraindicated in conditions like Renal diseases, Pneumonia, Liver diseases, Heart disease, Complicating secondary infection, Previous antimonial therapy.

Dosage

Sodium Stibogluconate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
8.57 mg/kg	8.57 mg/kg	Every 24h	IM	For 7-10 Days
8.57 mg/kg	8.57 mg/kg	Every 24h	Slow IV	For 7-10 Days
Paediatric Dosage (20kg)
10 mg/kg	10 mg/kg	Every 24h	Intra Muscular	-
10 mg/kg	10 mg/kg	Every 24h	Intra Venous	-
Neonatal Dosage (3kg)
10 mg/kg	10 mg/kg	Every 24h	Intra Muscular	-
10 mg/kg	10 mg/kg	Every 24h	Intra Venous	-

Drug Interactions

None recorded.

Side Effects

Sodium Stibogluconate in overdosage may give rise to further complications which include Venous thrombosis .

Sodium Stibogluconate produces potentially life-threatening effects which include Hepatotoxicity , Cardiotoxicity , Renal toxicity. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Sodium Stibogluconate are Renal failure, Circulatory collapse, Disseminated intravascular coagulopathy.

Sodium Stibogluconate is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Arthralgia, Malaise, Myalgia, Nausea and vomiting.

Warnings / Precautions

Safety of the sodium stibogluconate has not been determined in pregnant women , in the children <18 months and the breast feeding mothers.

Available Brands

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Single Ingredient

Inj

333 mg

Storage Conditions

Sodium Stibogluconate should be stored IV Inj, IM Inj.

Drug Classification

1.6.4.2 — Antileishmanial drugs

Manufacturers

Manufacturers of Sodium Stibogluconate in Pakistan:

Star