Sodium Thiosulphate
Sodium Thiosulphate used in the treatment of cyanide or arsenic poisoning in conjunction with sodium nitrite.
Primary Characteristics
It is of Synthetic origin.
It is classified in Antidotes pharmacological group.
Molecular Weight: 158.1 · pKa: 1.6 · Solubility in Water: 1 in 0.5 · Solubility in Alcohol: Insoluble · Non-proprietary name: Sodium Thiosulphate · pH: 7.4 · Isotonic value: 2.98.
Pharmacokinetics
Absorption: Sodium Thiosulphate has an oral bioavailability is 15.5% (±4.5%).
Distribution: Sodium Thiosulphate has a volume of distribution is 0.15 l/kg.
Elimination: plasma half-life is 0.3 - 3 hr.
Advertisement
Indications
Sodium Thiosulphate is primarily indicated in conditions like Cyanide poisoning, Poisoning with cyanogenic substances, Skin diseases.
Contraindications
Sodium Thiosulphate is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Sodium Thiosulphate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 17.86 mg/kg.min | 17.86 mg/kg.min | Every 24h | IV Inf | For 10 Minutes |
| Paediatric Dosage (20kg) | ||||
| 250 mg/kg | 250 mg/kg | — | Slow IV | Given over 10 Minutes |
| Neonatal Dosage (3kg) | ||||
| 250 mg/kg | 250 mg/kg | — | Slow IV | Given over 10 Minutes |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Sodium Thiosulphate in overdosage may give rise to further complications which include Itching, Hives, Irritation .
Sodium Thiosulphate produces potentially life-threatening effects which include Hypotension. Careful monitoring is needed with proper medical management.
Sodium Thiosulphate is known to cause more or less tolerable side effects which are usually transient. These include Burning, Stinging on application.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.4.2.7 — Cyanide poisoning