Sodium Salicylate
Sodium Salicylate reduces fever and relieves pain. itused in the symptomatic therapy of gout and in acute rheumatic fever.
Primary Characteristics
It is of Synthetic origin and belongs to Hydoroxybenzoate.
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 160.1 · pKa: 2.9, 13.4 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 11 · Non-proprietary name: Sodium Salicylate · pH: 6.7 · Isotonic value: 2.53.
Pharmacokinetics
Absorption: Sodium Salicylate has an oral bioavailability is 90% (±10%).
Distribution: Sodium Salicylate has a volume of distribution is 0.15 - 0.21 l/kg. plasma protein binding is 90 - 95 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 2 - 3 hr, renal excretion is 80 - 100 %.
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Indications
Sodium Salicylate is primarily indicated in conditions like Fever, Pain, Rheumatoid arthritis.
Contraindications
Sodium Salicylate is contraindicated in conditions like Peptic ulcer, Renal diseases, Gastritis.
Dosage
Sodium Salicylate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 6.61 mg/kg | 6.61 mg/kg | Every 4h | PO | - |
| 10.71 mg/kg | 10.71 mg/kg | Every 24h | Slow IV | - |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended under 12 Yrs Children |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Sodium Salicylate in overdosage may give rise to further complications which include Gastric irritation , Hepatotoxicity , Mucosal lesions, Worsening of pre-existing heart failure.
Sodium Salicylate produces potentially life-threatening effects which include Hypersensitivity reactions, Reye's syndrome. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Sodium Salicylate are Acidosis, Fever, Hyperglycemia, Renal failure, Hypoglycemia, Respiratory alkalosis.
Sodium Salicylate is known to cause more or less tolerable side effects which are usually transient. These include Hyperventilation , Metabolic acidosis, Rashes , Respiratory alkalosis, Salicylism , Tachycardia.
Warnings / Precautions
Interference in Pathology
Sodium Salicylate may interfere in the diagnosis of Test for Urinary Glucose, Oestrogens, 17-OH-Corticosteroids, Ketones , Serum Uric Acid Test .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)