Nadolol
Nadolol is oral, nonselective, beta-adrenergic receptor antagonist similar to propranolol. Chemically Nadolol is identified as (2R, 3S)-5-[ 3-(tert-butylamino)-2-hydroxypropoxy ]-1, 2, 3, 4-tetrahydronaphthalene-2, 3-diol. It does not demonstrate appreciable intrinsic sympathomimetic or membrane-stabilizing activities. Unlike propranolol, it possesses a low degree of lipid solubility and has the longest plasma half-life of all the beta-adrenergic-blocking agents. It was approved by the FDA in December 1989. The actions and uses similar to that of propranolol, but Nadolol is more potent than propranolol. It slows the heart rate and reduces high blood pressure
Primary Characteristics
It is of Synthetic origin and belongs to Catecholamine.
It belongs to Beta adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Beta Blocker, Nonselective pharmacological group.
Molecular Weight: 309.4 · pKa: 9.67 · Solubility in Water: Slightly soluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Nadolol.
Pharmacokinetics
Absorption: Nadolol has an oral bioavailability is 30%.
Distribution: Nadolol has a volume of distribution is 2 l/kg. plasma protein binding is 30 %.
Elimination: plasma half-life is 21 hr, renal excretion is 73 %.
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Indications
Nadolol is primarily indicated in conditions like Angina, Cardiac arrhythmia, Control of muscarinic side-effects of neostigmine, Hypertension, Hyperthyroidism, Migraine prophylaxis, Myocardial infarction, Thyrotoxicosis, To prevent recurrence of neural tube defect.
Contraindications
Nadolol is contraindicated in conditions like Cardiogenic shock, Heart block, Cardiac insufficiency, Obstructive airway disease.
Dosage
Nadolol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 140 mg | 140 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Nadolol produces potentially life-threatening effects which include Bronchospasm , Bronchospasm, Heart block, Heart failure, Asthma . Careful monitoring is needed with proper medical management.
Nadolol is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Amnesia , Bradycardia , Cardiac insufficiency, Confusion, Coolness of extremities, Depression, Dryness of mouth, Fatigue, Headache, Insomnia, Light headedness, Paresthesias.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.1 — Beta blocking agents