Dienoestrol
Also known as: Dienestrol, Dehydrostilbesteol, Dehydrostilboestrol, Dienostrol
Dienoestrol is a synthetic sex hormone. Dienoestrol is used to treat symptoms associated with menopause and for the suppression of lactation. Structurally similar to diethylstilibestestrol.
Primary Characteristics
Dienoestrol is also known as Dienestrol, Dehydrostilbesteol, Dehydrostilboestrol, Dienostrol.
It is of Synthetic origin and belongs to Alkyl Diphenol.
It belongs to Oestrogen Agonist pharmacological group on the basis of mechanism of action. It is also classified under Sex Hormones .
Molecular Weight: 266.3 · Solubility in Water: insoluble · Solubility in Alcohol: 1 in 8 · Non-proprietary name: Dienoestrol.
Pharmacokinetics
Distribution: Dienoestrol has a plasma protein binding is 50-80%.
Elimination: it is metabolised via unchanged 88%, Hepatic.
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Indications
Dienoestrol is primarily indicated in conditions like Atrophic vaginitis, Senile vaginitis, Vulvar squamous hyperplasia.
Dienoestrol is also indicated for secondary conditions like Oestrogen deficiency.
Contraindications
Dienoestrol is contraindicated in conditions like Pregnancy, Hypersensitivity to the drug, Endometrial hyperplasia.
Dosage
Dienoestrol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.01 % | 0.01 % | — | Intra Vaginal | Maint. on alternate days, as required |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Dienoestrol in overdosage may give rise to further complications which include Gall bladder disease .
Dienoestrol produces potentially life-threatening effects which include Hypercalcemia, Endometrial carcinoma, Breast cancer, Thromboembolic disease, Hepatic adenoma, Hypercalcemia. Careful monitoring is needed with proper medical management.
Dienoestrol is known to cause more or less tolerable side effects which are usually transient. These include Changes in LFT , Elevated blood pressure, Endometrial bleeding, GI upset, Hypersensitivity reactions, Hypersensitivity of lower vagina (vulva), Jaundice , Painful stimulation of breast, Salt retention, Water retention, Weight gain.
Warnings / Precautions
Interference in Pathology
Dienoestrol may interfere in the diagnosis of Certain Endocrine and Liver Function Tests .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.18.4 — Estrogens, their combinations and related preparations