Dicyclomine (HCl)
Also known as: Dicycloverine Hydrochloride
Dicyclomine (HCl) slows activity of the stomach and gastro-intestinal tract. Dicyclomine (HCl) used in treating spasm of gastro-intestinal tract and urinary tract and to reduce gastric acid in peptic ulceration. Dicyclomine (HCl) also used in diarrhea, irritable bowel syndrome, spastic colitis,m and biliary dyskinesia
Primary Characteristics
Dicyclomine (HCl) is also known as Dicycloverine Hydrochloride.
It is of Synthetic origin and belongs to Cyclohexyl Carboxylicacid.
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antispasmodic Agent pharmacological group. It is also classified under Gastrointestinal Anticholinergics/Antispasmodics .
Molecular Weight: 346 · Solubility in Water: 1 in 20 · Solubility in Alcohol: 1 in 5 · Non-proprietary name: Dicyclomine (HCl).
Pharmacokinetics
Distribution: Dicyclomine (HCl) has a volume of distribution is 3.65 l/kg 20mg oral dose. plasma protein binding is >99%.
Elimination: plasma half-life is 4-6 hr mean sh, renal excretion is 79.5%.
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Indications
Dicyclomine (HCl) is primarily indicated in conditions like Infantile colic, Irritable bowel syndrome, Symptomatic relief of GI-disorders, Urinary incontinence.
Contraindications
Dicyclomine (HCl) is contraindicated in conditions like Glucoma, Reflux oesophagitis, Prostatic hypertrophy.
Dosage
Dicyclomine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 20 mg | 20 mg | Every 6h | IM | |
| 15 mg | 15 mg | Every 8h | PO | |
| Paediatric Dosage (20kg) | ||||
| 7.5 mg | 7.5 mg | — | 3 to 4 times a day | |
| 0.75 mg/kg | 0.75 mg/kg | Every 8h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| 0.5 mg/kg | 0.5 mg/kg | Every 8h | oral | Avoid in children less than 6 months of age |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Dicyclomine (HCl) produces potentially life-threatening effects which include Respiratory arrest. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Dicyclomine (HCl) are Seizures, Dilated pupils, Fainting , Nausea & vomiting, Weakness .
Dicyclomine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, CNS effects, Constipation , Dizziness, Drowsiness, Exacerbation of glaucoma, Nausea, Photophobia , Problems of accomodation, Tachycardia, Urinary retensionX, Weakness, Xerostomia .
Warnings / Precautions
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.17.5 — Antispasmodics