Diethylcarbamazine (Citrate)

Drug #237

Diethylcarbamazine (Citrate) is anthelmintic agent. Diethylcarbamazine (Citrate) is used to treat filariasis (nematode infection).

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Primary Characteristics

It is of Synthetic origin and belongs to Piperazine.

It is classified in Anthelmintics pharmacological group.

Molecular Weight: 391.4 · pK_a: 7.7 · Solubility in Water: 1 in 1.25 · Solubility in Alcohol: 1 in 35 · Non-proprietary name: Diethylcarbamazine (Citrate).

Molecular structure of Diethylcarbamazine (Citrate)

Pharmacokinetics

Absorption: Diethylcarbamazine (Citrate) has an oral bioavailability is 94% (±4%).

Distribution: Diethylcarbamazine (Citrate) has a volume of distribution is 107-371 litre. plasma protein binding is Negligible.

Elimination: it is metabolised via Hepatic, plasma half-life is 10 hr, renal excretion is 90 (5% in faeces).

Indications

Diethylcarbamazine (Citrate) is primarily indicated in conditions like Filarial infection, Lymphatic filariasis, Onchoceriasis.

Contraindications

Diethylcarbamazine (Citrate) is contraindicated in conditions like Hypersensitivity to murine proteins.

Dosage

Diethylcarbamazine (Citrate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 mg/kg	1 mg/kg	Every 24h	PO	Initial
6 mg/kg	6 mg/kg	Every 8h	PO	Maintenance, Gradually increase as Required. for 3 weeks.
Paediatric Dosage (20kg)
1 mg/kg	1 mg/kg	Every 8h	Oral	Initially for 3 days
2 mg/kg	2 mg/kg	Every 8h	Oral	Maintenance for 21 Days
Neonatal Dosage (3kg)
1 mg/kg	1 mg/kg	Every 8h	Oral	Initially for 3 days
2 mg/kg	2 mg/kg	Every 8h	Oral	Maintenance for 21 Days

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Diethylcarbamazine (Citrate) produces potentially life-threatening effects which include Mazzotti Reaction , Conjunctivitis, Iridocyclitis, Visual field loss, Encephalitis, Retinal hemorrhage. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Diethylcarbamazine (Citrate) are Nausea, Vomiting, Drowsiness, Drowsiness, Dizziness.

Diethylcarbamazine (Citrate) is known to cause more or less tolerable side effects which are usually transient. These include Chills, dizziness, Drowsiness, Fever, Headache, Nausea.

Warnings / Precautions

Diethylcarbamazine should be used with caution in patients with renal impairment. Avoid use in infants, pregnant women, elderly or debiliated, especially in those with cardiac or renal disease. and in hyper sensitive pateints.

Available Brands

None recorded.

Storage Conditions

Diethylcarbamazine (Citrate) should be stored Tab.

Drug Classification

1.6.1.2 — Antifilarials