Cyproheptadine (HCl)

Drug #207

Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative properties, resembles the phenothiazine antihistaminic agents in chemical structure and has potent H1 receptor blocking actions.

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Primary Characteristics

Cyproheptadine (HCl) is also known as Epidroheptadine, Periactinol, Dronactin, Peritol, Ciproheptadina, Cyproheptadine, Cyproheptadinum.

It is of Synthetic origin and belongs to Benzopiperidine.

It belongs to Antimuscorinic , Antimuscorinic , Antimuscorinic , H2 and 5HT antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 350.9 · Solubility in Water: 1 in 275 · Solubility in Alcohol: 1 in 35 · Non-proprietary name: Cyproheptadine (HCl).

Molecular structure of Cyproheptadine (HCl)

Pharmacokinetics

Distribution: Cyproheptadine (HCl) has a plasma protein binding is 90 to 99%.

Elimination: it is metabolised via Hepatic, plasma half-life is 1-4 hr, renal excretion is 50%.

Indications

Cyproheptadine (HCl) is primarily indicated in conditions like Acromegaly, Advanced ovarian cancer, Angioedema, Anorexia nervosa, Antidepressant-induced inorgasmia, Appetite stimulation, Carcinoid syndrome, Cushing's syndrome, Hyperprolactinaemia, Migraine, Nelsons syndrome, NSAID associated ulceration, Pruritus, Symptomatic relief of allergy, To prevent recurrence of neural tube defect, Urticaria, Vascular headaches.

Cyproheptadine (HCl) is also indicated for secondary conditions like Severe nausea, vomiting (prevention).

Contraindications

Cyproheptadine (HCl) is contraindicated in conditions like Asthma, Glucoma, Prostatism, Pyloric stenosis.

Dosage

Cyproheptadine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
6 mg	6 mg	Every 8h	PO	It may be given 4 times daily.
Paediatric Dosage (20kg)
2.1 mg/kg	2.1 mg/kg	Every 8h	Oral	-
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cyproheptadine (HCl) in overdosage may give rise to further complications which include Tachycardia , Hypotension , Psychiatric disturbances , Hypotension , Neurological disturbances , Palpitation , Urinary retention, Wheezing , Nasal blockage , GI upsets, Difficulties in micturition, Urinary retention.

Cyproheptadine (HCl) produces potentially life-threatening effects which include Blood dyscrasias, Hepatitis , Anaphylactic reactions. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Cyproheptadine (HCl) are Flushing, Vomiting, Convulsions , Hallucinations , Dilated pupils, Ataxia, CNS depression.

Cyproheptadine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Dry mouth, Fatigue, Increased appetite, Nausea, Weight gain.

Warnings / Precautions

Cyproheptadine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer subcutaneously because irritation or lesion may occur.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Syrup

2 mg/5ml

Tabs

4 mg

Multi-Ingredient Combinations

Syrup

1.5 mg/5ml

Storage Conditions

Cyproheptadine (HCl) should be stored Tab.

Drug Classification

1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis

Manufacturers

Manufacturers of Cyproheptadine (HCl) in Pakistan:

Highnoon Medicraft Progressive Lab Siza Stanley