Cyproterone (Acetate)
Also known as: Androcur, Cyprosteroacetate, Androcur cypeostan, Cyproferoneacetate
Cyproterone (Acetate) is a hormone. Cyproterone (Acetate) is used in the treatment of prostate cancer, sexual disorders in male, hirsutism in women and acne etc.
Primary Characteristics
Cyproterone (Acetate) is also known as Androcur, Cyprosteroacetate, Androcur cypeostan, Cyproferoneacetate, Cyprostat.
It is of Synthetic origin and belongs to Steroid.
It belongs to Androgen antagonist , Androgen antagonist pharmacological group on the basis of mechanism of action and also classified in Anti Allergic Agent pharmacological group.
Molecular Weight: 416.9 · Solubility in Water: insoluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Cyproterone (Acetate).
Pharmacokinetics
Absorption: Cyproterone (Acetate) has an oral bioavailability is 97% (±2%).
Distribution: Cyproterone (Acetate) has a volume of distribution is 1320 ± 580 litre. plasma protein binding is 96%.
Elimination: it is metabolised via Hepatic, plasma half-life is 43 hr, renal excretion is 35%.
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Indications
Cyproterone (Acetate) is primarily indicated in conditions like Androgenic acne, Androgenic alopecia, Flare with initial gonadorelin therapy, Hirsutism, Idiopathic precocious puberty, Inoperable prostatic carcinoma, Male hypersexuality, Male-female transsexualism, Prostate cancer (metastatic), flare with initial gonadorelin therapy, Prostate cancer (metastatic), hot flushes with gonadorelin therapy, Prostate cancer (metastatic), long-term palliative therapy, Prostate cancer, flare with initial gonadorelin therapy, Prostate cancer, hot flushes with gonadorelin therapy, Prostate cancer, long-term palliative therapy, Prostatic cancer.
Contraindications
Cyproterone (Acetate) is contraindicated in conditions like Sickle cell anaemia, Liver diseases, Thromboembolism, Chronic depression.
Dosage
Cyproterone (Acetate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0 – 0 | — | — | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cyproterone (Acetate) in overdosage may give rise to further complications which include Azoospermia , Oligozoospermia .
Cyproterone (Acetate) produces potentially life-threatening effects which include Jaundice , Hepatic failure. Careful monitoring is needed with proper medical management.
Cyproterone (Acetate) is known to cause more or less tolerable side effects which are usually transient. These include Decreased FSH, Decreased LDL concentrations, Decreased LH, Decreased libido, Fall in fasting plasma glucose , Fatigue, Gynecomastia, Increased plasma triglycerides, Increased prolactin, Negative nitrogen balance, Weakness.
Warnings / Precautions
Interference in Pathology
Cyproterone (Acetate) may interfere in the diagnosis of Artefactual increase in cortisol plasma levels by Fluorometry .
Available Brands
Storage Conditions
Drug Classification
- 1.8.3 — Hormones and antihormones
Manufacturers
Manufacturers of Cyproterone (Acetate) in Pakistan: