Ganirelix

Drug #1787

Ganirelix is a gonadotrophin releasing hormone (GnRH) antagonist, that inhibits the release of gonadotrophins (Follicle-stimulating hormone and Luteinising hormone). Ganirelix is used in the treatment of infertility by assisted reproductive techniques.

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Primary Characteristics

It is of Synthetic origin and belongs to GnRH antagonist.

Molecular Weight: 1690.4 · Non-proprietary name: Ganirelix.

Pharmacokinetics

Absorption: Ganirelix has an oral bioavailability is 45.5% (±45.5%).

Distribution: Ganirelix has a volume of distribution is 43.7 L3, 76.5 L2. plasma protein binding is 81.9%.

Elimination: plasma half-life is 13 hrs, renal excretion is 22.1%.

Indications

Ganirelix is primarily indicated in conditions like Infertility.

Contraindications

Ganirelix is contraindicated in conditions like Pregnancy, Breast feeding, Pain and inflammation (rheumatic disease), Listerial meningitis (adjunct).

Dosage

Ganirelix's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
250 mcg	250 mcg	—	SC	In the morning (or each afternoon) starting on day 6 of ovarian stimulation with gonadotrophins.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Ganirelix is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Dyspneoa, Facial edema, Headache, Injection-site reactions, Malaise, Rash, Vaginal bleeding.

Warnings / Precautions

Ganirelix Acetate Injection should be prescribed by physicians who are experienced in infertility treatment. Before starting treatment with Ganirelix Acetate, pregnancy must be excluded. Safe use of Ganirelix Acetate during pregnancy has not been established Latex allergy, congenital anomalies, Lactation. It is Pragnancy category.

Interference in Pathology

Ganirelix may interfere in the diagnosis of Hematocrit Value , Total Bilirubin, Neutrophil count.

Available Brands

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Single Ingredient

Inj

0.25 mg/0.5ml

Storage Conditions

Ganirelix should be stored .

Drug Classification

1.18.6 — Ovulation stimulants

Manufacturers

Manufacturers of Ganirelix in Pakistan:

Obs