Galantamine

Drug #1718

Galantamine is a reversible inhibitor of cholinestrase activity and it also has nicotinic receptor agonist properties. The actions and general properties similar to neostigmine. Galantamine is used in the treatment of mild to moderate dementia in Alzheimer`s disease and in various neuromuscular disorders.

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Primary Characteristics

It is of Semi Synthetic origin.

Molecular Weight: 368.3 · Solubility in Water: Sparingly soluble in water · Solubility in Alcohol: Very Slightly Soluble · Non-proprietary name: Galantamine.

Pharmacokinetics

Absorption: Galantamine has an oral bioavailability is 45% (±45%).

Distribution: Galantamine has a plasma protein binding is 18.

Elimination: plasma half-life is 7-8, renal excretion is 20.

Indications

Galantamine is primarily indicated in conditions like Mild to moderate dementia in alzheimer's disease.

Galantamine is also indicated for secondary conditions like Muscle relaxation.

Contraindications

Galantamine is contraindicated in conditions like Breast feeding, Adjunct in treatment of opioid dependance.

Dosage

Galantamine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
4 mg	4 mg	Every 12h	PO	Four weeks later, the dose should be increased to 8 milligrams twice a day. After waiting an additional four weeks, the doctor may increase the dose to 12 milligrams twice a day if necessary.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Galantamine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Bradycardia , Diarrhea, Drowsiness, Dyspepsia , Fatigue, Headache, Hypertension , Muscle cramps, Nausea and vomiting, Tremors, UTI , Weight LossX.

Warnings / Precautions

Galantamine should be used with caution in patients with hepatic impairment (avoid if severe); sick sinus syndrome or other supraventricular conduction abnormalities; susceptibility to peptic ulcer; asthma, chronic obstructive pulmonary disease; may exacerbate extrapyramidal symptoms; hepatic impairment.

Available Brands

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Single Ingredient

Oral Soln

4 mg/ml

Tabs

12 mg 4 mg 8 mg

Drug Classification

1.1.4 — Muscle relaxants and cholinesterase inhibitors

Manufacturers

Manufacturers of Galantamine in Pakistan:

Janssen-Cilag Reko