Lofexidine

Drug #1716

Lofexidine (HCl) is an alpha-2 receptor agonist similar to clonidine. It appears to act centrally to produce reduction in sympathetic tone, but reduction in blood pressure is less marked. Lofexidine (HCl) is used for the symptomatic management of opiod withdrawal.

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Primary Characteristics

Lofexidine is also known as Lofexidine (HCl).

It is of Synthetic origin.

Molecular Weight: 259.13 · Non-proprietary name: Lofexidine.

Pharmacokinetics

Distribution: Lofexidine has a plasma protein binding is 80-90%.

Elimination: it is metabolised via Hepatic glucuronidation, plasma half-life is 11 hours, renal excretion is Urine.

Indications

Lofexidine is primarily indicated in conditions like Hypertension, Opiate withdrawal syndrome.

Contraindications

Lofexidine is contraindicated in conditions like Hypersensitivity.

Dosage

Lofexidine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
600 Ug	600 Ug	—	PO	Maintanace dose to a maximum of 2.4 mg daily, the maximum single dose should not exceed 800ug.
800 Ug	800 Ug	—	PO	Initial oral dose in divided doses
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Moderate6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Lofexidine in overdosage may give rise to further complications which include Bradycardia , Prolongation of QI interval.

The signs and symptoms that are produced after acute overdosage of Lofexidine are Sedation .

Lofexidine is known to cause more or less tolerable side effects which are usually transient. These include Bradycardia , Drowsiness, Dry mouth, Dry mucous membrane (perticularly dry mouth, throat, and nose), Hypotension , Rebound hypertension on withdrawl.

Warnings / Precautions

Lofexidine should be used with caution in patients with severe coronary insufficiency, recent myocardial infarction, cerebrovascular disese, marked bradycardia (monitor pulse rate frequently); renal impairment; history of depression (on longer tretment); pregnancy and breast feeding; withdraw gradually over 2-4 days (or longer) to minimize risk of rebound hypertension and associated symptoms. Donot drive because Lofexidine may cause drowsiness. Withdrawl of lofexidine therapy should be gradual.

Available Brands

None recorded.

Drug Classification

1.4.2.2 — Opioid analgesic overdose