Peginterferon Alfa-2a (rbe)
Peginterferon alfa-2a (rbe) is a polyethylene glycol-conjugated derivative of interferon alpha. Peginterferon alfa-2a (rbe) is licensed for the treatment of chronic hepatitis C, ideally in combination with ribavirin.
Primary Characteristics
It is of Semi Synthetic origin.
Non-proprietary name: Peginterferon Alfa-2a (rbe).
Pharmacokinetics
Distribution: Peginterferon Alfa-2a (rbe) has a volume of distribution is 6-14 litres.
Elimination: plasma half-life is 77 hr.
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Indications
Peginterferon Alfa-2a (rbe) is primarily indicated in conditions like Chronic hepatitis C.
Contraindications
Peginterferon Alfa-2a (rbe) is contraindicated in conditions like Psychiatric disease, Cardiac disease, Hepatic dysfunction, Autoimmune hepatitis.
Dosage
Peginterferon Alfa-2a (rbe)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 180 mcg | 180 mcg | — | SC | this dose is given once weekly by SC inj. into abdomen or thigh given in combination with oral ribarvirin. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Peginterferon Alfa-2a (rbe) is known to cause more or less tolerable side effects which are usually transient. These include Anemia, Anorexia , Depression, Fatigue, Flu like syndrome, GI upset, Headache, Insomnia, Myalgia, Pyrexia , Rigors , Skin reactions.
Warnings / Precautions
Interference in Pathology
Peginterferon Alfa-2a (rbe) may interfere in the diagnosis of Thyroid Function Test.
Available Brands
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Single Ingredient
Drug Classification
- 1.8.1 — Immunomodulators