Chlorzoxazone

Drug #1629

Chlorzoxazone is a centrally acting skeletal muscle relaxant with sedative properties. Chlorzoxazone is used as an adjunct in the symptomatic treatment of painful muscle spasm. It inhibits muscle spasm by exerting its effect at the level of the spinal cord and subcortical area of the brain. Chlorzoxazone is usually given with analgesics in compound preparations.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 169.6 · Solubility in Water: slightly soluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Chlorzoxazone.

Pharmacokinetics

Elimination: plasma half-life is 1-2 hr.

Indications

Chlorzoxazone is primarily indicated in conditions like Muscular spasm.

Contraindications

Chlorzoxazone is contraindicated in conditions like Hypersensitivity.

Dosage

Chlorzoxazone's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
500 mg	500 mg	Every 6h	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Chlorzoxazone in overdosage may give rise to further complications which include Respiratory depression , Hypotension , Hypotension .

Chlorzoxazone produces potentially life-threatening effects which include Hepatotoxicity . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Chlorzoxazone are Drowsiness, Dizziness, Headache, GI disturbances, Drowsiness, Malaise.

Chlorzoxazone is known to cause more or less tolerable side effects which are usually transient. These include Sedation , Skin rashes.

Warnings / Precautions

Chlorzoxazone should not be given to patients with impaired liver function and should be discontinued if signs of liver toxicity appear. Patient should be advised to report the doctor if any sign or symptom of possible liver toxicity appear such as fever, rash, jaundice, dark urine, anorexia, nausea, vomiting or right upper quadrant pain. The drug should only be used in pregnancy if clearly needed. Patients should observe caution while driving or performing other tasks requiring alertness. The urine of the patient taking chlorzoxazone may be coloured orange or reddish-purple by a phenolic metabolite.

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Caps

250 mg

Storage Conditions

Chlorzoxazone should be stored Caps.

Drug Classification

1.20 — Muscle relaxants and cholinesterase inhibitors

Manufacturers

Manufacturers of Chlorzoxazone in Pakistan:

Delta