Chloral Betaine

Also known as: Cloral betaine

Drug #1631

Chloral Betaine is used in the short-term management of insomnia. It dissociates in the stomach to release chloral hydrate, therefore, has actions and uses similar to those of chloral hydrate.

← Previous drug Next drug →

Primary Characteristics

Chloral Betaine is also known as Cloral betaine.

It is of Synthetic origin and belongs to Chloral hydrate betaine.

Molecular Weight: 282.6 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 4 · Non-proprietary name: Chloral Betaine.

Pharmacokinetics

Distribution: Chloral Betaine has a volume of distribution is 0.61 l/kg. plasma protein binding is 35%.

Elimination: it is metabolised via via liver, plasma half-life is 4-5 min, renal excretion is 40%.

Indications

Chloral Betaine is primarily indicated in conditions like Insomnia, Postoperative sedation, Pre-operative sedation.

Contraindications

Chloral Betaine is contraindicated in conditions like Renal failure, Gastritis, Hepatic failure, Porphyria, Cardiac disease.

Dosage

Chloral Betaine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1050 mg	1050 mg	Every 24h	PO	Should be taken 15-30 min before bed time.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Chloral Betaine in overdosage may give rise to further complications which include Bradycardia , Eosinophilia , CNS depression, Hypoprothorombinemia, Hepatic encephalopathy exacerbation.

Chloral Betaine produces potentially life-threatening effects which include Hepatic coma, Leukopenia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Chloral Betaine are Coma, Lethargy, Cardiac arrhythmias, Ataxia, Respiratory depression.

Chloral Betaine is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Disorientation, Drowsiness, GI symptoms, Skin RashX.

Warnings / Precautions

Patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness. Do not use in larger doses in patients with severe cardiac disease. Exercise caution in administering to patients prone to addiction. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because may produced allergic reaction (including bronchial asthma).

Interference in Pathology

Chloral Betaine may interfere in the diagnosis of Assay of Glucose (Benedics Test), Steroids and Urea .

Available Brands

None recorded.

Storage Conditions

Chloral Betaine should be stored Tabs.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders