Obidoxime (Cl)
Obidoxime (Cl) is a cholinesterase reactivator with similar actions and uses pralidoxime. Obidoxime (Cl) is given in combination with atropine in the treatment of organophosphorous poisoning.
Primary Characteristics
It is of Synthetic origin.
Molecular Weight: 359.2 · pKa: 7.7 · Solubility in Water: 1 in 2 · Solubility in Alcohol: 1 in 1000 · Non-proprietary name: Obidoxime (Cl).
Pharmacokinetics
Distribution: Obidoxime (Cl) has a volume of distribution is 0.17 l/Kg. plasma protein binding is negligible.
Elimination: plasma half-life is 83 +/- 10 min.
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Indications
Obidoxime (Cl) is primarily indicated in conditions like Acute poisoning with organophosphorus ester.
Contraindications
Obidoxime (Cl) is contraindicated in conditions like Hypersensitivity.
Dosage
Obidoxime (Cl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 250 mg | 250 mg | — | Slow I/V injection | over 24 hours followed by i/v infusion of 750 mg over 24 hours |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | ||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Obidoxime (Cl) in overdosage may give rise to further complications which include Mania , Excitement , Non-oliguric renal failure, Transient liver damage.
Obidoxime (Cl) produces potentially life-threatening effects which include Cardiac arrhythmia, QT prolongation. Careful monitoring is needed with proper medical management.
Obidoxime (Cl) is known to cause more or less tolerable side effects which are usually transient. These include Dry mouth, feeling of coldness in nasopharynx, Hot feeling in facial area, Tachycardia, Transient hypotension.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.4.2.3 — Organophosphate and carbamate poisoning