Piretanide

Drug #1544

Piretanide is a loop diuretic with actions, uses and adverse effects similar to those of frusemide. Piretanide is used in the management of mild to moderate hypertension associated with edema.

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Primary Characteristics

It is of Synthetic origin and belongs to Sulfamoyl Benzoic Acid Derivative.

Molecular Weight: 362.4 · pK_a: 3.9 · Solubility in Water: low · Solubility in Alcohol: low · Non-proprietary name: Piretanide.

Pharmacokinetics

Absorption: Piretanide has an oral bioavailability is 86% (±6%).

Distribution: Piretanide has a volume of distribution is 12 - 17 litre. plasma protein binding is 94 %.

Elimination: plasma half-life is 1 - 1.5 hr, renal excretion is 45 % unchanged.

Indications

Piretanide is primarily indicated in conditions like Ascites, Chronic liver disease, Hypertension, Nephrotic syndrome, Oedema in congestive heart failure, Pulmonary edema, Renal insufficiency.

Piretanide is also indicated for secondary conditions like Prophylaxis of renal transplant rejection.

Contraindications

Piretanide is contraindicated in conditions like Gout, Hypovolaemia, Hypokalaemia, Anuria, Hepatic coma, Dehydration, Hypersensitivity, Pregnancy, Lactation.

Dosage

Piretanide's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
15 mg/day	15 mg/day	—	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown5 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Piretanide in overdosage may give rise to further complications which include Urinary retention, Hyponatremia , Thrombocytopenia , Ototoxicity , Orthostatic hypotension , Leucopenia, Dehydration , Gout .

Piretanide produces potentially life-threatening effects which include Cardiac arrhythmia, Hypotension, Renal failure, Increased renal excretion of Ca, K, Mg. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Piretanide are Dehydration, Hypovolemia, Delirium, Decreased sodium and water.

Piretanide is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Digestive disturbances, Erythema, Itching, Nausea, Urticaria, Vomiting .

Warnings / Precautions

It should be used with caution in patients with diabetes, kidney or liver disease or any drug allergy. Caution must be observed when eating large amounts of food high in potassium such as bananas, baked potatoes, raisins, cooked spinach and other foods. Alcoholic beverages may increase the effects of this drug, causing dizziness or lightheadedness, so limit alcohol intake. It should be used with caution while engaging in activities requiring alertness. This drug changes fluid balance, cause dizziness, if change from a lying to a standing position too rapidly, avoid this by sitting up a few minutes before rising. It should be used with caution during pregnancy or lactation.

Available Brands

None recorded.

Storage Conditions

Piretanide should be stored Caps.

Drug Classification

1.16.2 — Loop diuretics