Norgestimate

Drug #1546

Norgestimate is a progestogen structurally related to levonorgestrel. Norgestimate is used as a part of progestogenic part of combined oral contraceptives.

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Primary Characteristics

It is of Synthetic origin and belongs to Progestogen.

Molecular Weight: 369.5 · Solubility in Water: Insoluble · Solubility in Alcohol: 1 in 170 · Non-proprietary name: Norgestimate.

Pharmacokinetics

Absorption: Norgestimate has an oral bioavailability is 50% (±50%).

Distribution: Norgestimate has a plasma protein binding is 99 %.

Elimination: plasma half-life is 16.5 hr, renal excretion is 46.8 +/- 1 %.

Indications

Norgestimate is primarily indicated in conditions like Oral contraception.

Contraindications

Norgestimate is contraindicated in conditions like Breast cancer, Circulatory system disease, Liver diseases, Genital bleeding, Disturbance of lipid metabolism.

Dosage

Norgestimate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
250 µg	250 µg	Every 1h		Used in triphasic preparation for 3 days
0 – 0 tab	—	Every 24h	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown8 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Norgestimate in overdosage may give rise to further complications which include Hypertension .

Norgestimate produces potentially life-threatening effects which include Venous thromboembolism, Ischemic heart disease, Cerebrovascular disease. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Norgestimate are Nausea, Vaginal bleeding, Vomiting.

Norgestimate is known to cause more or less tolerable side effects which are usually transient. These include Acne, Changes in libido , Depressive moods, Headache, Nausea, Weight gain.

Warnings / Precautions

It should be used with caution in patients with any allergy (especially drug allergy), abnormal vaginal bleeding, liver, kidney or heart disease, cancer of the breast or genitals, missed abortion, blood clots, seizures, migraine, asthma, depression or diabetes. Limit alcohol, as this may increase side effects of this drug. It shold be used with caution while performing tasks requiring mental alertness (e.g.driving) as this drug may cause drowsiness.

Interference in Pathology

Norgestimate may interfere in the diagnosis of Serum Tests for Adrenal Corticosteroids , Urine Tests for 17-Ketosteroids and 17-OH Corticosteroids and Aldosterone , Thyopac Method for Measurement of T3 .

Available Brands

None recorded.

Storage Conditions

Norgestimate should be stored . Tab .

Drug Classification

1.18.5 — Progestogens