Rofecoxib
Rofecoxib is NSAID (non-steroidal antinfalmmatory drug) and a selective COX-2 inhibitor. It reduces swelling and relieves the pain. Rofecoxib is used for symptomatic relieve of pain in osteoarthritis.
Primary Characteristics
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 314.36 · Solubility in Water: Insoluble · Solubility in Alcohol: very slightly soluble · Non-proprietary name: Rofecoxib.
Pharmacokinetics
Distribution: Rofecoxib has a volume of distribution is 1.23l/kg. plasma protein binding is 87 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 17 hr, renal excretion is < 1 %.
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Indications
Rofecoxib is primarily indicated in conditions like Dysmenorrhoea, Osteoarthritis, Pain, Rheumatoid arthritis, Schizophrenia and other psychoses.
Contraindications
None recorded.
Dosage
Rofecoxib's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 25 mg | 25 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Rofecoxib is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Increased intracranial pressure, Nausea.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)