Propoxyphene
Propoxyphene is a structural analogue of methadone with spectrum of pharmacologic activity similar to that of codeine.
Primary Characteristics
It belongs to Aminopropionic Acid.
It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesic-Narcotic pharmacological group. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 339.5 · Solubility in Water: very slightly soluble · Solubility in Alcohol: soluble · Non-proprietary name: Propoxyphene.
Pharmacokinetics
Elimination: it is metabolised via Hepatic, plasma half-life is 6 -12 hr.
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Indications
Propoxyphene is primarily indicated in conditions like Pain.
Contraindications
Propoxyphene is contraindicated in conditions like Paralytic ileus, Respiratory depression, Hypersensitivity to any component of product, Severe asthma.
Dosage
Propoxyphene's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.18 mg/kg | 1.18 mg/kg | Every 4h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Propoxyphene is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Dizziness, Drowsiness, Fatigue, Headache, Hypotension , Insomnia, Light headedness, Malaise, Paradoxical effects, Restlessness, Sedation , Weakness.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.2.2 — Opioid analgesics