DrugInfoSys

Bisacodyl

Drug #98

Bisacodyl is a stimulant laxative. Chemically Bisacodyl is identified as 4, 4'-(2-pyridylmethylene)diphenol diacetate. It acts by irritating the digestive tract and stimulates intestinal activity. Bisacodyl is effective in treating constipation or to clean out the intestinal tract before bowel examinations or bowel surgery.

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Primary Characteristics

It is of Synthetic origin and belongs to Phenyl Pyridine.

It belongs to Laxatives pharmacological group on the basis of mechanism of action and also classified in Stimulant pharmacological group.

Molecular Weight: 361.4 · Solubility in Water: very slight · Solubility in Alcohol: 1 in 100 · Non-proprietary name: Bisacodyl.

Molecular structure of Bisacodyl

Pharmacokinetics

Absorption: Bisacodyl has an oral bioavailability is 7.5% (±7.5%).

Elimination: it is metabolised via Hepatic, renal excretion is 30%.

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Indications

Bisacodyl is primarily indicated in conditions like Bowel evacuation, Bowel preparation, Constipation, Prior to radiological procedures and surgery.

Contraindications

Bisacodyl is contraindicated in conditions like Intestinal obstruction, Dehydration.

Dosage

Bisacodyl's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
10 mg10 mgEvery 24hPOAt Bed Time
Paediatric Dosage (20kg)
0.5 mg/kg0.5 mg/kgEvery 24hIntra Rectal -
0.5 mg/kg0.5 mg/kgEvery 24hOral -
Neonatal Dosage (3kg)
0.312 mg/kg0.312 mg/kgEvery 24horalAt night
0.312 mg/kg0.312 mg/kgEvery 24hRectalIn morning

Drug Interactions

None recorded.

Side Effects

Bisacodyl in overdosage may give rise to further complications which include Malabsorption , Potassium depletion , Diarrhoea , Protein-losing gastroenteropathy .

Bisacodyl is known to cause more or less tolerable side effects which are usually transient. These include Cramps , Gastric irritation, Nausea, Vomiting .

Warnings / Precautions

Bisacodyl should not be given to patients with intestinal obstruction or with undiagnosed abdominal symptoms. It should be used with care in patients with inflammatory bowl disease. Prolong use should be avoided. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because may cause allergic reactions (including bronchial asthma). Discontinue use if skin eruption occured.

Interference in Pathology

Bisacodyl may interfere in the diagnosis of Falsely low readings for urinary glucose with Clintest and Diastix but not with Testape .

Available Brands

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Single Ingredient

Tabs
5 mg

Storage Conditions

Bisacodyl should be stored Suppositories, Enema. Tab.

Drug Classification

  1. 1.17.6 — Laxatives

Manufacturers