Biperiden (HCl)

Drug #97

Biperiden (HCl) is a antimuscarinic and anti-spasmodic agent. Biperiden (HCl) is used as an adjunct in the therapy of parkinsonism (defeciency of dopamine) of all causes.

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Primary Characteristics

It is of Synthetic origin and belongs to Piperidine.

It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.

Molecular Weight: 347.9 · Solubility in Water: 1 in 100-1 in 1000 · Solubility in Alcohol: 1 in 100-1 in 1000 · Non-proprietary name: Biperiden (HCl).

Pharmacokinetics

Absorption: Biperiden (HCl) has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 70%.

Distribution: Biperiden (HCl) has a volume of distribution is 4030 litre. plasma protein binding is 95%.

Elimination: plasma half-life is ~18 hr, renal excretion is major.

Indications

Biperiden (HCl) is primarily indicated in conditions like Acute dystonic reactions, Oculogyric crises, Parkinsonism, Pseudo-parkinsonism.

Contraindications

Biperiden (HCl) is contraindicated in conditions like Tardive dyskinesias, Cardiac dysrhythmias.

Dosage

Biperiden (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.16 mg/kg	0.16 mg/kg	Every 24h	IM	-
0.16 mg/kg	0.16 mg/kg	Every 24h	IV	-
0.05 mg/kg	0.05 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Biperiden (HCl) in overdosage may give rise to further complications which include Toxic confusional state .

Biperiden (HCl) produces potentially life-threatening effects which include Cardiac arrhythmias. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Biperiden (HCl) are Tachycardia , Dry mucous membrane, Dry skin, Flushing, Dilated pupils.

Biperiden (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Dry mouth, GI symptoms.

Warnings / Precautions

Biperiden should be used with caution in patients with heart, liver, kidney or obstructive gastrointestinal (GI) diseases. Patient should observe caution while driving or performing other tasks requiring alertness because may impair mental or physical abilities. It should be used with caution in hot weather. Reduce dose or discontinue therapy if loss of appetite or weight occur.

Available Brands

None recorded.

Storage Conditions

Biperiden (HCl) should be stored Inj. Tab.

Drug Classification

1.17.5 — Antispasmodics