Potassium Iodide
Potassium Iodide is oral antithyroid agent. Potassium Iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution. The drug is also useful as a protectant of the thyroid gland following radiation exposure and has demonstrated efficacy in treating cutaneous sporotrichosis. Although itwas used as an expectorant for conditions such as cystic fibrosis, chronic bronchitis, and bronchial asthma, Potassium Iodide is no longer recommended because evidence of clinical efficacy is lacking for this indication. Potassium Iodide is approved by the FDA in 1939. Exerts its action in the thyroid gland, by inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell size is reduced, follicular colloid reaccumulates, and bound iodine levels increase. As a protectant following radiation exposure, KI blocks the uptake of radioactive iodine isotopes by the thyroid gland thereby minimizing the risk of radiation-induced thyroid neoplasms.
Primary Characteristics
It belongs to Potassium Salt.
It is classified in Anticataractogenic pharmacological group. It is also classified under Opthalmic Products .
Molecular Weight: 166 · Solubility in Water: 1 in 0.7 · Solubility in Alcohol: 1 in 22 · Non-proprietary name: Potassium Iodide · pH: 7 · Isotonic value: 2.59.
Pharmacokinetics
None recorded.
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Indications
Potassium Iodide is primarily indicated in conditions like Cataract.
Potassium Iodide is also indicated for secondary conditions like Diabetes mellitus, Hypertension, Myopia, Periphlebitis.
Contraindications
Potassium Iodide is contraindicated in conditions like Hyperthyroidism.
Dosage
Potassium Iodide 's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.15 mg | 0.15 mg | Every 8h | Ophthalmic | - |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Potassium Iodide in overdosage may give rise to further complications which include Hyperthyroidism .
Potassium Iodide is known to cause more or less tolerable side effects which are usually transient. These include Acne, Burning, Lacrimation, Pricking sensation.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.18.8 — Thyroid & antithyroid preparations
- 2.21.7 — Other ophthalmologicals