Pergolide

Pergolide should be used with caution in patients with pre-existing heart disease or a history of heart arrhythmias (abnormal rhythms), hallucinations, mental confusion, difficulty in walking, allergies, kidney disease or low blood pressure. Caution should be exercised when administering pergolide mesylate to patients prone to cardiac dysrhythmias. In a study comparing pergolide mesylate and placebo, patients taking pergolide mesylate were found to have signifiscantly more episodes premature contractions (PACs) and sinus tachycardia. Patients and their families should be informed of the common adverse consequences of the use of pergolide mesylate and the risk of hypotension. Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy. Patients should be advised to notify their physician if they are breast feeding an infant. Liver disease may alter the response to drugs in several ways. Prescribing should be kept to a minimum in all patients with severe liver disease, especially if jaundice, ascites, or evidence of encephalopathy present. Consider dose reduction in renal failure to avoid possibility of toxicity, increased sensitivity, and side effects. Get up slowly, to avoid dizziness and lightheadedness when rising from a seated or lying position. It should be used with caution when performing tasks requiring mental alertness such as driving or using machinery. Limit alcohol use because it may intensify the drowsiness and dizziness effects of this drug. It should be used with caution during pregnancy.