Pentoxifylline

Also known as: Oxpentifylline

Drug #959

Pentoxifylline is a vasodilator, used in the treatment of peripheral vascular disease like intermittant claudication, Raynaud's syndrome. It may be useful in lowering blood sugar level, also reduces blood presure. Caution may be needed if given with antihypertensive or insulin as it may increase their effects

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Primary Characteristics

Pentoxifylline is also known as Oxpentifylline.

It is of Synthetic origin and belongs to Xanthine.

It belongs to Phosphodiesterase inhibitor , Anticonjuctivitis pharmacological group on the basis of mechanism of action and also classified in Vasodilators pharmacological group.

Molecular Weight: 278.3 · pK_a: 0.28 · Solubility in Water: soluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Pentoxifylline.

Pharmacokinetics

Absorption: Pentoxifylline has an oral bioavailability is 48.5% (±48.5%).

Distribution: Pentoxifylline has a volume of distribution is 168 litres. plasma protein binding is low.

Elimination: it is metabolised via hepatic, plasma half-life is 0.4 - 0.8 hr, renal excretion is >95%.

Indications

Pentoxifylline is primarily indicated in conditions like Cerebrovascular disease, Circulatory system disease, Raynaud`s phenomenon.

Pentoxifylline is also indicated for secondary conditions like Peripheral vascular disease, Venous leg ulcers.

Contraindications

None recorded.

Dosage

Pentoxifylline's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
400 mg	400 mg	Every 8h	PO
Paediatric Dosage (20kg)
0 – 0	—	—		Safety not established
Neonatal Dosage (3kg)
0 – 0	—	—		Safety not established

Drug Interactions

Unknown4 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Pentoxifylline are Bradycardia, AV block.

Pentoxifylline is known to cause more or less tolerable side effects which are usually transient. These include GI distention, Headache, Nausea, Pruritus , Urticaria, Vomiting .

Warnings / Precautions

Give pentoxifylline with caution to patients with chronic occlusive arterial disease of limb because it can cause other arteriosclerotic disease. Monitor the systemic blood pressure (B.P) especially in patients receiving antihypertensive drugs.

Interference in Pathology

Pentoxifylline may interfere in the diagnosis of Urinary Estimation of Pregnanediol by Gas Chromatographic Assay. .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

100 mg/5ml

Tabs

400 mg

Storage Conditions

Pentoxifylline should be stored Tab.

Drug Classification

1.12.8 — Other cardiovascular preparations
2.24.6 — Cerebrovascular drugs

Manufacturers

Manufacturers of Pentoxifylline in Pakistan:

Neo