Perindopril

Drug #961

Perindopril is angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, and various renal syndromes such as diabetic nephropathy and scleroderma. Perindopril is a prodrug, converted to an active form before exerting its effect.it has affinity for ACE and competes with angiotensin I, the natural substrate, to block its conversion to angiotensin II. Angiotensin II is a potent vasoconstrictor and a negative feedback mediator for renin activity. Thus, as a result of lower angiotensin II plasma levels, blood pressure decreases and plasma renin activity increases. Decreases in plasma angiotensin II levels reduce aldosterone secretion, with a subsequent decrease in sodium and water retention. It also dilates arterioles, thereby lowering total peripheral vascular resistance.

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Primary Characteristics

Perindopril is also known as Perindopril Erbumine.

It belongs to Indole.

It belongs to Angiotensin converting enzyme inhibitor-ACEI pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.

Molecular Weight: 368.47 · Solubility in Water: freely soluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Perindopril.

Pharmacokinetics

Distribution: Perindopril has a plasma protein binding is 60%.

Elimination: it is metabolised via extensively Hepatic, plasma half-life is 0.8-1 hrs, renal excretion is 75 %.

Indications

Perindopril is primarily indicated in conditions like Congestive heart failure, Heart failure, Heart failure (adjunct), Hypertension, Myocardial infarction.

Contraindications

Perindopril is contraindicated in conditions like Aortic stenosis, Angioedema, Hypersensitivity to the drug.

Dosage

Perindopril's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 mg	2 mg	—	PO	For Congestive heart failure: Dose may be increased to 4 mg once blood pressure acceptability has been demonstrated.
4 mg	4 mg	—	PO	For Hypertension: once daily.
4 mg	4 mg	—	PO	For Coronary artery disease: 4 mg for 2 weeks then uptitration to 8 mg once daily.
6 mg	6 mg	—	PO	Increased to max. after 1 month therapy
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown4 interactions

Major3 interactions

Moderate13 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Perindopril in overdosage may give rise to further complications which include Thrombocytopenia , Leucopenia, Neutropenia , Paresthesia, Myocardial infarction .

The signs and symptoms that are produced after acute overdosage of Perindopril are Hypothermia, Circulatory arrest.

Perindopril is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Asthenia , Constipation , Cough , Diarrhea, Dizziness, Dry cough, Dyspepsia , Epigastric discomfort, Fatigue, Headache, Mood swings, Nausea, Rashes , Taste disturbances, Tinnitus.

Warnings / Precautions

Regular renal function tests advised during prolonged treatment with Perindopril Erbumine. Care with initial dose due to postural hypotension. Avoid perindopril in patients with reno-vascular disease or aortic stenosis. Caution in patients with history of serosal inflammatory conditions. In hypertensive patients with unilateral or bilateral renal artery stenosis, increases in blood urea nitrogen and serum creatinine may occur. Experience with ACE inhibitors suggests that these increases are usually reversible upon discontinuation of the drug. In such patients, renal function should be monitored during the first few weeks of therapy. Treatment should start under close medical supervision. Avoid use during pregnancy.

Interference in Pathology

Perindopril may interfere in the diagnosis of Abnormal renal function test, Serum bilirubin raised, Serum creatinin raised.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

2 mg 4 mg 8 mg

Multi-Ingredient Combinations

Tabs

2 mg 4 mg 8 mg

Storage Conditions

Perindopril should be stored Tab.

Drug Classification

1.12.3.3 — ACE inhibitors

Manufacturers

Manufacturers of Perindopril in Pakistan:

CSH Neutro Novamed Servier