Oxybuprocaine

Also known as: Benoxinate HCl

Drug #949

Oxybuprocaine most widely used topical local anesthetic which is used especially in opthalmolgy and otolaryngology. Oxybuprocaine (HCl) used as the hydrochloride in a 0.4% solution in short opthalmological procedures to produce surface anaesthesia of the eye.

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Primary Characteristics

Oxybuprocaine is also known as Benoxinate HCl, Oxybuprocaine (HCl).

It belongs to Ester type.

It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Local Anesthetics pharmacological group.

Molecular Weight: 344.9 · Solubility in Water: very soluble · Solubility in Alcohol: 1 in 2.6 · Non-proprietary name: Oxybuprocaine · pH: 4.5.

Pharmacokinetics

None recorded.

Indications

Oxybuprocaine is primarily indicated in conditions like Local anaesthesia for eye, Surface anaesthetic.

Contraindications

Oxybuprocaine is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Oxybuprocaine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.4 %	0.4 %	—	Ophthalmic	As required
Paediatric Dosage (20kg)
0 – 0	—	—		SA
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Oxybuprocaine is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Hypotension , Nausea.

Warnings / Precautions

Avoid Oxybuprocaine in patient with known hypersensitivity. It should be given with caution to the elderly, to debilitated, to children, patients with epilepsy, impaired cardiac conduction or respiratory function, shock or liver damage. It might be ototoxic and should not be instilled into the middle ear. The application of local anesthetics to the skin for prolonged period or to the extensive area should be avoided.

Available Brands

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Single Ingredient

Eye Drops

0.4 %w/v

Storage Conditions

Oxybuprocaine should be stored Eye Drops.

Drug Classification

1.1.2 — Local anesthetics
2.21.7 — Other ophthalmologicals

Manufacturers

Manufacturers of Oxybuprocaine in Pakistan:

Ethical