Oxybutynin (HCl)
Oxybutynin (HCl) is anticholinergic and antispasmodic agent. Chemically Oxybutynin (HCl) is identified as (R, S)-4-diethylamino-2-butynylphenyl-cyclohexylglycolate. Oxybutynin (HCl) is used to treat urinary incontinance (both sensory and motor), and nocturnal enuresis. Oxybutynin (HCl) is prepared by chemical synthesis. Oxybutynin (HCl) is optically active and the racemate is used clinically. Oxybutynin (HCl) is not avaialble in any combination preparations. Oxybutynin (HCl) is administered orally.
Primary Characteristics
It belongs to Tertiary Amine.
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antispasmodic Agent, Urinary pharmacological group. It is also classified under Antidotes .
Molecular Weight: 393.9 · Solubility in Water: freely Soluble · Solubility in Alcohol: freely Soluble · Non-proprietary name: Oxybutynin (HCl).
Pharmacokinetics
Distribution: Oxybutynin (HCl) has a volume of distribution is 193 litre.
Elimination: it is metabolised via Hepatic, plasma half-life is 2.5 hr, renal excretion is < 0.1% (unchanged).
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Indications
Oxybutynin (HCl) is primarily indicated in conditions like Neurogenic bladder, Severe or recurrent duodenal and gastric ulcertion, Urinary frequency, Urinary spasm.
Contraindications
Oxybutynin (HCl) is contraindicated in conditions like Glucoma, Myasthenia gravis, Ulcerative colitis, Mega colon, Intestinal atony, GI obstruction.
Dosage
Oxybutynin (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5 mg | 5 mg | Every 12h | PO | Frequency may be increased upto 3 times/day if needed. |
| Paediatric Dosage (20kg) | ||||
| 0.2 mg/kg | 0.2 mg/kg | Every 12h | Oral | Not recommended for below 5 yrs. of children |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Oxybutynin (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Diaphoresis, Dizziness, Drowsiness, Fever, Headache, Hot flushes, Insomnia, Nausea and vomiting, Palpitation, Tachycardia, Xerostomia .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.29 — Drugs used in renal, bladder, and prostatic disorders