DrugInfoSys

Nitrofurazone

Also known as: Nitrofural

Drug #942

Nitrofurazone is a local antibacterial agent, effective against a wide variety of gram positive and gram negative oragnisms. Nitrofurazone is used topically in the treatment of mixed, superficial infection of skin. Nitrofurazone is effective especially in the treatment of second and third degree burns and in skin grafting. Nitrofurazone is slowly acting drug and atleast 24 hours are required for it to take effect properly. Therefore, no treatment should be less than 2 or 3 days in duration.

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Primary Characteristics

Nitrofurazone is also known as Nitrofural.

It is of Synthetic origin and belongs to Nitrofuran.

It is classified in Antibiotic, Topical pharmacological group. It is also classified under Dermatological Products .

Molecular Weight: 198.1 · Solubility in Water: Very slightly soluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Nitrofurazone.

Molecular structure of Nitrofurazone

Pharmacokinetics

Elimination: plasma half-life is 5 hour.

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Indications

Nitrofurazone is primarily indicated in conditions like Bacterial infections, Bladder irrigation, Burns and ulcers, Dermatosis, Otitis media, Skin infections, Wounds.

Contraindications

Nitrofurazone is contraindicated in conditions like Renal impairment.

Dosage

Nitrofurazone's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.2 %0.2 %—Topical 2-4 times daily
Paediatric Dosage (20kg)
0 – 0——SA
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Nitrofurazone in overdosage may give rise to further complications which include Peripheral neuropathy , Thromboembolic disorder .

Nitrofurazone is known to cause more or less tolerable side effects which are usually transient. These include Allergic skin reactions, Calf pain, Chest pain, Depression, Dyspnea, Headache, Loss of vision , Numbness or weakness in extremity , Pain , Shortening of breath, Vision disturbances, Vomiting .

Warnings / Precautions

Because of the risk of haemolysis, nitrofurazone by mouth should be used with caution in patients with glucose-6-phosphate dehydrogenase deficiency. Avoid use topical nitrofurazone in patients with known hypersensitivity. Preparations containing macrogil should be used with caution in renal impairment.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Cream
0.2 %w/w
Powder
0.2 %w/w

Storage Conditions

Nitrofurazone should be stored Cream, Oint, Topical Soln.

Drug Classification

  1. 1.13.2.1 — Antibacterials, topical

Manufacturers

Manufacturers of Nitrofurazone in Pakistan:

GSKHizatLiskoPharmawiseProgressive LabSharexZafa