Nimesulide

Nimesulide must be used with care among patients with a history of bleeding, with illnesses of the upper gastrointestinal tract and to subjects undergoing treatment with anticoagulants or drugs that inhibit platelet aggregation. The patients must be under direct medical supervision while taking substances with limited gastric tolerance at the same time. Since the drug is eliminated mainly through the kidneys, patient with the renal insufficiency must have a lower dosage depending on the glomerular filtration rate. The product must not be administered to the patient with severe renal insufficiency. The product can cause water retention, therefore it must not be administered to the patient with reduced cardiac function. Patients whose activity require alertness must take the product with care in case they notice drowsiness or vertigo during therapy . Cases of visual disturbances when using other non-steroidal anti-inflammatory drugs have been reported, If eye problems appear, the treatment must be interrupted and an eye examination must be performed.