Naphazoline
Naphazoline is a sympathomimetic agent with marked alpha-adrenergic activity. Chemically Naphazoline is 2-(1-naphthylmethyl)-2-imidazoline. Naphazoline is used topically on nasal mucosa where its vasoconstrictor effect leads to reduce secretion and mucosal swelling (e.g in allergic rhinitis). Prolonged use may lead to rebound nasal congestion and secretion. Naphazoline is also used in allergic and inflammtory condition of eyes.
Primary Characteristics
It belongs to Imidazole.
It belongs to Alpha adrenergic agonist pharmacological group on the basis of mechanism of action.
Molecular Weight: 210.27 · Solubility in Water: freely soluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Naphazoline · pH: 5.3 · Isotonic value: 3.99.
Pharmacokinetics
None recorded.
Advertisement
Indications
Naphazoline is primarily indicated in conditions like Corneal vascularity, Hyperaemia, Itching, Nasal congestion.
Naphazoline is also indicated for secondary conditions like Sinusitis.
Contraindications
Naphazoline is contraindicated in conditions like Asthma, Diabetes mellitus, Narrow-angle glaucoma.
Dosage
Naphazoline's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.05 – 0.1 % | — | Every 4h | Intra Nasal | 1-2 drops or spray in each nostril, not more than 3 to 5 days |
| 0.1 % | 0.1 % | Every 4h | Ophthalmic | 1 - 2 drops. Not more than 3 to 4 days |
| Paediatric Dosage (20kg) | ||||
| 0.05 % | 0.05 % | — | Children aged 7 years & over | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Naphazoline in overdosage may give rise to further complications which include Rebound congestion , Increased IOP (intraocular pressure).
The signs and symptoms that are produced after acute overdosage of Naphazoline are Bradycardia, Coma, Sweating , Sweating, CNS depression.
Naphazoline is known to cause more or less tolerable side effects which are usually transient. These include Blurring of vision, Dizziness, Dry mouth, Headache, Irritation, Mydriasis, Nausea, Nervousness, Sneezing, Stinging on application.
Warnings / Precautions
Available Brands
Click on a strength to view available brands.
Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.21.6 — Non-specific anticonjunctivitis preparations
- 2.25.4 — Nasal preparations