Montelukast
Montelukast (Na) is oral leukotriene receptor antagonist. Blocks part of the inflammatory process associated with an asthma attack and thus helps to reduce swelling or constriction of airways. Used as an add-on therapy inthe long term management of asthma when treatment with inhaled corticosteroids and beta-adrenoceptor stimulants is inadequate. May cause headache and abdominal pain.
Primary Characteristics
Montelukast is also known as Montelukast (Na).
It is of Synthetic origin and belongs to Cyclopropanacetic Acid.
Molecular Weight: 608.2 · Solubility in Water: freely Soluble · Solubility in Alcohol: freely Soluble · Non-proprietary name: Montelukast.
Pharmacokinetics
Absorption: Montelukast has an oral bioavailability is 32% (±32%).
Distribution: Montelukast has a volume of distribution is 8 - 11 liter. plasma protein binding is > 99 %.
Elimination: it is metabolised via Exlenerly hepatic cyp 3A4 &2C9, plasma half-life is 2.7 - 5.5 hr, renal excretion is < 0.2 %.
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Indications
Montelukast is primarily indicated in conditions like Asthma, Prophylaxis of asthma.
Montelukast is also indicated for secondary conditions like Allergic rhinitis.
Contraindications
None recorded.
Dosage
Montelukast's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 4 – 10 mg | — | Every 24h | PO | With or without meal at bed time. |
| Paediatric Dosage (20kg) | ||||
| 0.2 mg/kg | 0.2 mg/kg | Every 24h | Oral | For 6--14 Yrs |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Montelukast in overdosage may give rise to further complications which include Anxiousness.
Montelukast produces potentially life-threatening effects which include Angioedema . Careful monitoring is needed with proper medical management.
Montelukast is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Agitation , Allergy anaphylaxis, Headache, Increased sweating, Oedema, Restlessness.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.25.1.1 — Oral/Parenteral antiasthmatics
Manufacturers
Manufacturers of Montelukast in Pakistan: