Molgramostim
Molgramostim is a human growth factor made by recombinant DNA technology with actions and uses similar to Filgrastim. It stimulates the production of white blood cells in bone marrow. Molgramostim is used to increase the white blood cell production in patient whose bone marrow function is depressed by cancer therapy. Molgramostim is also being used in the treatment of AIDS.
Primary Characteristics
It is of Semi Synthetic origin and belongs to .
It belongs to Granulocyte colony stimulating factor agonist pharmacological group on the basis of mechanism of action and also classified in Colony Stimulating Factor pharmacological group. It is also classified under Hematological Agents .
Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Molgramostim.
Pharmacokinetics
Distribution: Molgramostim has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Molgramostim is primarily indicated in conditions like Acceleration of myeloid recovery following bone marrow transplantation, Adjunct in ganciclovir treatment, AIDS, Aplastic anemia, Bone marrow transplantation, Cytotoxic chemotherapy, Leucopaecia, Leukopenia, Myclodysplastic syndrome, Myelodysplastic syndrome.
Molgramostim is also indicated for secondary conditions like Cancer.
Contraindications
Molgramostim is contraindicated in conditions like Myeloid leukaemia.
Dosage
Molgramostim's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5.5 ug/kg | 5.5 ug/kg | Every 24h | IV Inf | Bone marrow transplantation |
| 7.5 ug/kg | 7.5 ug/kg | Every 24h | SC | An adjunct to antineoplastic theropy for 7 to 10 days. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Molgramostim produces potentially life-threatening effects which include Cardiac arrhythmias, Cardiac failure, Anaphylactic reactions. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Molgramostim are Convulsions , Cerebrovascular disorders.
Molgramostim is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Asthenia , Chest pain, Chills, Confusion, Diarrhea, Dizziness, Dyspnea, Fatigue, Flushing, Headache, Hypotension, Nausea, Pruritus , Rashes , Rigors , StomatitisX, SweatingX, Syncope , Vomiting .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.10.4 — Anabolics & hematopoietics