Moclobemide

Drug #933

Moclobemide is oral antidepressant agent acts by selective inhibiton of monoamine oxidase type A in the brain. Increases brain monoamines by reducing their enzyme breakdown. Acts more rapidly than earlier MAOIs such as Phenelzine, and causes fewer side effects. Moclobemide is effective in the treatment of depression in patients who are allergic or untreated with tricyclic antidepressants.

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Primary Characteristics

It belongs to Benzamide.

It is classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 268.7 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Moclobemide.

Pharmacokinetics

Distribution: Moclobemide has a plasma protein binding is 50%.

Elimination: it is metabolised via Liver, plasma half-life is 2-4hr.

Indications

Moclobemide is primarily indicated in conditions like Autoimmune conditions, Depression, Social phobia.

Contraindications

Moclobemide is contraindicated in conditions like Phaeochromocytoma, Thyrotoxicosis, Acute confusion states.

Dosage

Moclobemide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
150 mg	150 mg	Every 24h	PO	Maintenance.
300 mg	300 mg	Every 24h	PO	Dose may be increased by 600 mg.
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended for this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown11 interactions

3 interactions

Major2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Moclobemide is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Constipation , Dizziness, Headache, Insomnia, Nausea and vomiting, parasthesia, Visual disturbances.

Warnings / Precautions

Patient should be closely monitored during early antidepressant therapy until improvement in depression is observed because suicide is an inherent risk in depressed patients. Moclobemide should be avoided in exited or agitated patients or those with severe hepatic (liver) impairment. Care should also required in patients with thyrotoxicosis as moclobemide may precipitate hypertensive reaction.

Available Brands

None recorded.

Storage Conditions

Moclobemide should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression