Dorzolamide

The preservative in this medication may be absorbed by soft contact lenses; therefore, it is recommended that soft contact lenses not be worn while using this medication. Dorzolamide should not be administered to patients with carbonic anhydrase inhibitor hypersensitivity. In addition, since dorzolamide is a sulfonamide derivative, it should not be used in patients with sulfonamide hypersensitivity. Topical administration of dorzolamide can result in systemic absorption. In sulfonamide-sensitive patients, administration of sulfonamides by any route can precipitate a possibly severe reaction. Its use as a single agent is insufficient for the management of closed-angle glaucoma. The use of multiple dose containers of ophthalmic products has been associated with bacterial keratitis. Inadvertent contamination of the product may occur if the patient has an ocular infection, or corneal abrasion. If there is any damage to the ocular epithelial surface dorzolamide should be used with caution. It should be used with caution in patients with hepatic disease. It is classified as pregnancy category C. Should be use during pregnancy only if the benefits outweigh the possible risks to the fetus. Cuation:- Systemic alesorption follows topical application; history of renal calculi; chronic corneal defects, history of intra-ocular surgury.