Drotaverine
Drotaverine is Cholinergic muscarinic antagonist. Drotaverine is used in smooth muscle spasm and stone formation.
Primary Characteristics
Drotaverine is also known as Drotaverine Hcl.
It belongs to Papavecine.
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antispasmodic Agent pharmacological group.
Molecular Weight: 397.5 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Drotaverine.
Pharmacokinetics
None recorded.
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Indications
Drotaverine is primarily indicated in conditions like Biliary spasm, Cholangitis, Cholecystitis, Cholecytolithiasis, Cystitis, Nephrolithiasis, Papilitis, Smooth muscle spasm, Stone formation, Ureterolithiasis, Urinary spasm, Urolithiasis, Vesical tenesmus.
Contraindications
Drotaverine is contraindicated in conditions like Cardiac insufficiency, Renal insufficiency, Hepatic insufficiency, Av block of ii &iii degree.
Dosage
Drotaverine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | Every 8h | IV,IM | |
| 120 – 240 mg | — | Every 3h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Drotaverine in overdosage may give rise to further complications which include Porphyria.
Drotaverine is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Dizziness, Dry mouth, Headache, Hypotension , Insomnia, Nausea, Palpitation, Vertigo, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.17.5 — Antispasmodics