Citalopram (HBr) - Drug Monograph

Primary Characteristics

Citalopram (HBr) is also known as citalopram hydrobromide, Citalopram.

It is of Synthetic origin and belongs to Benzofuran.

It is classified in Antidepressant pharmacological group.

Molecular Weight: 405.3 · pK_a: 9.5 · Solubility in Water: sparingly soluble · Solubility in Alcohol: soluble · Non-proprietary name: Citalopram (HCl).

Pharmacokinetics

Absorption: Citalopram (HBr) has an oral bioavailability is 50% (±50%), pre-systemic (first-pass) metabolism accounts for 10.5% (±10.5%).

Distribution: Citalopram (HBr) has a volume of distribution is 14 l/kg. plasma protein binding is 70-80%.

Elimination: it is metabolised via Hepatic, plasma half-life is 23-75 hr, renal excretion is 12%.

Indications

Citalopram (HBr) is primarily indicated in conditions like Alcohol dependence, Depression, Obsessive-compulsive disorders, Panic disorders.

Contraindications

Citalopram (HBr) is contraindicated in conditions like Mania.

Dosage

Citalopram (HBr)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 mg	15 mg	Every 24h	PO
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown6 interactions

4 interactions

Major1 interaction

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Citalopram (HBr) in overdosage may give rise to further complications which include Bradycardia .

Citalopram (HBr) produces potentially life-threatening effects which include Hypertensive crises, Manic attacks. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Citalopram (HBr) are Respiratory depression, Respiratory depression, Convulsions , Hypoxia, Respiratory depression, Cardiotoxicity .

Citalopram (HBr) is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Dry mouth, Headache, increased cysetile weight again, Insomnia, Nausea, Sedation , SomnolenceX, SweatingX, Tremor, Vomiting , Xerosis.

Warnings / Precautions

Citalopram should be used with caution in hepatic or severe renal impairment, during pregnancy and lactation.

Interference in Pathology

Citalopram (HBr) may interfere in the diagnosis of Urinanalysis .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Syrup

10 mg/5ml

Tabs

10 mg 20 mg 40 mg

Multi-Ingredient Combinations

Syrup

40 mg/ml

Storage Conditions

Citalopram (HBr) should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression