Benzhexol (HCl)
Also known as: Trihexyphenidyl
Benzhexol (HCl) is anti-spasmodic drug. It relieves the abdominal pain and cramps. Benzhexol (HCl) is used in parkinsonism (mental disorder) of all cuases.Like atropine it also causes dry mouth , blurred vision, constipation, confusion and hallucinations. Salicylate of neostigmine is its effcetive antidote.
Primary Characteristics
Benzhexol (HCl) is also known as Trihexyphenidyl.
It is of Synthetic origin and belongs to Piperidinepropanol.
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.
Molecular Weight: 337.9 · Solubility in Water: 1 in 100 · Solubility in Alcohol: 1 in 22 · Non-proprietary name: Benzhexol (HCl).
Pharmacokinetics
Absorption: Benzhexol (HCl) has an oral bioavailability is 100%.
Elimination: plasma half-life is 3.3-4.1hrs, renal excretion is 56%.
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Indications
Benzhexol (HCl) is primarily indicated in conditions like Extrapyramidal disorders, Parkinsonism.
Benzhexol (HCl) is also indicated for secondary conditions like Advanced ovarian cancer.
Contraindications
Benzhexol (HCl) is contraindicated in conditions like Narrow-angle glaucoma, Hypersensitivity to the drug, Glaucoma.
Dosage
Benzhexol (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 – 2 mg daily | — | Every 24h | PO | Trihexyphenidyl HCl in Idiopathic Parkinsonism:1mg is administered on first day and then increased by 2mg increments at intervals of three to five days, until a total of 6 to 10 mg is given daily. The total daily dose will depend upon what is found to be the optimal level. Many patients derive maximum benefit from this daily total of 6 to 10 mg, but some patients, chiefly those in the post-encephalitic group, may require a total daily dose of 12 to 15 mg. |
| 5 – 15 mg daily | — | Every 24h | PO | Trihexyphenidyl HCl in Drug-Induced Parkinsonism:It may be advisable to commence therapy with a single 1 mg dose. If the extrapyramidal manifestations are not controlled in a few hours, the subsequent doses may be progressively increased until satisfactory control is achieved. |
| Paediatric Dosage (20kg) | ||||
| 0.16 mg/kg | 0.16 mg/kg | Every 24h | Oral | Not recommended under 3 yrs. Dose for 5-12 Yrs of Children |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended under 3 yrs. | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Benzhexol (HCl) in overdosage may give rise to further complications which include Tachycardia .
Benzhexol (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Confusion, Dizziness, Drowsiness, Euphoria, Hallucination , Headache.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.9.1 — Drugs used in parkinsonism
- 2.17.5 — Antispasmodics