Benztropine (Mesylate)
Also known as: Benzatropine
Benztropine (Mesylate) is a synthetic compound combining the active moieties of atropine and diphenylhydramine. It has anticholinergic, antihistaminic and local anesthetic effects. Benztropine (Mesylate) is antimuscarinic drug of potency one quater that of atropine sulphate and an antihistaminic of potency equal to that of pyrilamine maleate. It also has an antispasmodic properties. Benztropine (Mesylate) is used as an antidyskinetic in the treatment of parkinsonism and for the control of extrapyramidal reactions. Administered orally, intramuscularly and intravenously.
Primary Characteristics
Benztropine (Mesylate) is also known as Benzatropine.
It is of Synthetic origin and belongs to Tropane Alkaloid .
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antiparkinson Agents pharmacological group.
Molecular Weight: 403.5 · pKa: 10.0 · Solubility in Water: 1 in 0.7 · Solubility in Alcohol: 1 in 1.5 · Non-proprietary name: Benztropine (mesylate).
Pharmacokinetics
Distribution: Benztropine (Mesylate) has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Benztropine (Mesylate) is primarily indicated in conditions like Acute dystonic reactions, Idiopathic parkinsons disease, Postencephalitic parkinsonism.
Contraindications
Benztropine (Mesylate) is contraindicated in conditions like Glucoma, Prostatic hypertrophy.
Dosage
Benztropine (Mesylate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.011 mg/kg | 0.011 mg/kg | Every 24h | PO | Initial |
| 0.05 mg/kg | 0.05 mg/kg | Every 24h | PO | Maintenance |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Benztropine (Mesylate) in overdosage may give rise to further complications which include Blindness , Paralytic ileus .
Benztropine (Mesylate) produces potentially life-threatening effects which include Paralytic ileus. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Benztropine (Mesylate) are Dry flushed skin, Palpitations , Convulsions , Pyrexia, Nausea, Vomiting, Coma, Delirium, Blurred vision.
Benztropine (Mesylate) is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Confusion, Dry mouth, Hallucination .
Warnings / Precautions
Interference in Pathology
Benztropine (Mesylate) may interfere in the diagnosis of Frigs TLC procedures for measuring alkaloids in urine .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.17.5 — Antispasmodics