Cefpirome
Cefpirome is a fourth generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefpirome is effective in a large variety of bacterial infections, such as respiratory tract, ear, skin, septicaemia, infections in immunocompromized patients and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect.This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefpirome is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Primary Characteristics
Cefpirome is also known as Cefpirome Sulphate.
It is of Semi Synthetic origin and belongs to Cephalosporin.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin pharmacological group.
Molecular Weight: 612.7 · Solubility in Water: 1 in 2 · Non-proprietary name: Cefpirome.
Pharmacokinetics
Distribution: Cefpirome has a volume of distribution is 16.5 litre. plasma protein binding is 8.2-11.7%.
Elimination: plasma half-life is 1.4-2.3 hr, renal excretion is 70-90.
Advertisement
Indications
Cefpirome is primarily indicated in conditions like Bacteremia, Lower respiratory tract infections, Pneumonia, Promyelocytic leukemia, Septicaemia, Severe infections including bacteraemia and septicaemia and infections in neutropenic patients, Skin infections, Soft tissue infections, Urinary tract infection.
Contraindications
Cefpirome is contraindicated in conditions like Hypersensitivity.
Dosage
Cefpirome's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.5 g | 1.5 g | Every 12h | IV | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cefpirome in overdosage may give rise to further complications which include Thrombocytopenia , Granulocytopenia , Agranulocytosis , Eosinophilia , Hemolytic anemia , Hemolytic anemia , Eelvated hepatic enzymes , Superinfection .
Cefpirome produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.
Cefpirome is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Increase in liver enzymes, Nausea, Pseudomembranous colitis , Rashes , Urticaria, Vomiting .
Warnings / Precautions
Interference in Pathology
Cefpirome may interfere in the diagnosis of Jaffe method for determining Creatinine.
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins