Ceforanide
Ceforanide is a second generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Ceforanide is effective in a large variety of bacterial infections, such as respiratory tract, ear, skin, urinary tract infections, and surgical infection prophylaxis. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Ceforanide is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Cephem Carboxylic Acid.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin pharmacological group.
Molecular Weight: 519.6 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Ceforanide.
Pharmacokinetics
Distribution: Ceforanide has a plasma protein binding is 80%.
Elimination: plasma half-life is 2-3 hr, renal excretion is 90%.
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Indications
Ceforanide is primarily indicated in conditions like Bone and joint infection, Endocarditis, Respiratory tract infections, Skin infections, Surgical infections, Urinary tract infection.
Contraindications
Ceforanide is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Ceforanide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 750 mg | 750 mg | Every 12h | IV,IM | |
| Paediatric Dosage (20kg) | ||||
| 15 mg/kg | 15 mg/kg | Every 12h | Intra Muscular | - |
| 15 mg/kg | 15 mg/kg | Every 12h | Intra Venous | - |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended below 1 yr. | |
Drug Interactions
None recorded.
Side Effects
Ceforanide in overdosage may give rise to further complications which include Leucopenia, Paresthesia, Gi bleeding , Neutropenia , Proteinuria , Lymphocytosis , Agranulocytosis , Eosinophilia , Hemolytic anemia .
Ceforanide produces potentially life-threatening effects which include Renal failure. Careful monitoring is needed with proper medical management.
Ceforanide is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Chills, Dizziness, Dyspnea, Skin rashes, Urticaria, Vomiting .
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins