Cefpodoxime
Cefpodoxime is a third-generation broad spectrum ß lactamase resistant cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefpodoxime is effective against a wide range of range of gram positive and gram negative bacteria. Administered orally. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefpodoxime (Proxetil) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Primary Characteristics
Cefpodoxime is also known as Cefpodoxime (Proxetil).
It is of Semi Synthetic origin and belongs to Cephem Carboxylic Acid.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.
Molecular Weight: 557.6 · pKa: 3.2 · Solubility in Water: 1 in 6700 · Solubility in Alcohol: readily soluble · Non-proprietary name: Cefpodoxime.
Pharmacokinetics
Absorption: Cefpodoxime has an oral bioavailability is 50%, pre-systemic (first-pass) metabolism accounts for 100%.
Distribution: Cefpodoxime has a volume of distribution is 31-43 litre. plasma protein binding is 21-29%.
Elimination: plasma half-life is 1.9-3.2 hr, renal excretion is 40%.
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Indications
Cefpodoxime is primarily indicated in conditions like Benign gastric, duodenal or NSAID-associated ulceration, Gonorrhoea, Gynecological infections, Local infiltration, Lower respiratory tract infections, Otitis media, Sinusitis, Skin and soft tissue infections, Soft tissue and skin infections, Uncomplicated UTIs, Upper respiratory tract infections, Urinary tract infection.
Contraindications
Cefpodoxime is contraindicated in conditions like Hypersensitivity.
Dosage
Cefpodoxime's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 150 mg | 150 mg | Every 12h | PO | Dose varies according to indication |
| Paediatric Dosage (20kg) | ||||
| 4 mg/kg | 4 mg/kg | Every 12h | Oral | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cefpodoxime in overdosage may give rise to further complications which include Eosinophilia , Eosinophilia , Purpuric nephritis, anaphylactic shock, Acute liver injury, Hemolytic anemia , Stevens johnson syndrome , Stevens johnson syndrome , Anaphylactic shock, Hemolytic anemia , Hemolytic anemia, Thrombocytopenia .
Cefpodoxime produces potentially life-threatening effects which include Pseudomembranous colitis , Intravascular coagulation. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Cefpodoxime are Diarrhea, Epigastric distress, Nausea & vomiting.
Cefpodoxime is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Chills, Diarrhea, dizziness, Dyspnea, Fatigue, Glossitis, Urticaria, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins
Manufacturers
Manufacturers of Cefpodoxime in Pakistan: